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FDA approves first RSV vaccine for at-risk adults in their 50s
The Food and Drug Administration has approved giving GSK’s vaccine for respiratory syncytial virus down to age 50 years old, to those who are at higher risk of severe RSV, the company said Friday, making it the first shot greenlit for use in this age group to guard against RSV.
Global vaccine and drugmaker GSK asked the FDA in February to expand approval beyond adults 60 and older, citing data showing the immune response in adults vaccinated from this younger age group looked similar. Further trials are planned looking at adults between 18 and 49 years old, GSK said, with results expected in the second half of this year.
Two other companies – Pfizer and Moderna – also manufacture RSV vaccines approved for adults 60 and older, and are testing their shots in younger adults. Pfizer told investors last month it was getting ready to submit “positive” data from studies of its own shot down to age 18.
GSK’s vaccine will next need to be recommended for adults between 50 and 59 years old by the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices. Their backing, at upcoming meetings in June or October, would tee up insurance coverage.
Vaccinating adults in their 50s for RSV likely has a public health benefit, a work group within the CDC’s committee concluded last year ahead of the approval, though it is narrower than for older adults who are at higher risk from their age alone.
Under 60 years old, pre-existing medical issues play larger roles in the risk of RSV infections taking a dangerous turn.
“A lot of disease comes because the virus is triggering your underlying medical conditions, whether it’s COPD, heart failure, etc. So the virus is more of a trigger for exacerbation,” said Dr. Phil Dormitzer, senior vice president and global head of vaccines research and development at GSK.
Dormitzer said GSK had seen “relatively comparable” safety results from its vaccine in this group, compared to when it was given to those 60 and over. Some of the vaccine’s side effects did look to be a little stronger, likely as a result of better immune responses in this age group.
The CDC panel has also previously wrestled with rare but serious cases of a neurological disorder called Guillain-Barré syndrome seen after the use of the RSV shots.
Around 1.5 cases of the syndrome per million doses given of GSK’s vaccine have been reported, the CDC said last week. The agency’s survey data has found that close to a quarter of adults ages 60 and older had received an RSV shot since they were approved last year.
GSK’s trials did not turn up any “concerning” trends of GBS cases in the 50 to 59 age group, Dormitzer said.
“The risk of GBS tends to go up, it’s another one of those risks that tends to go up, with age. But there’s nothing to indicate that there’s any particular risk of GBS,” he said.
The CDC panel is also expected to weigh the possibility of whether and when adults will need to start getting booster shots for RSV.
Dormitzer said GSK is planning on presenting more trial results to the CDC committee in June, looking at boosters spaced out as much as three years after an initial shot.
“This is a really key question. People originally anticipated it might have to be an every year immunization. But then we found the duration of protection actually lasts for more than one season, clearly,” he said.
When Huntington Beach, Calif., detectives searched Rodney Alcala‘s Seattle storage locker during the murder investigation of 12-year-old Robin Samsoe in 1979, they discovered a cache of photos, many of them young women in suggestive, and even pornographic poses.
In March 2010, after a third jury in 30 years handed Alcala a death sentence, Huntington Beach police released more than 100 of those photos hoping to identify the women and some children, and learn if Alcala claimed still more victims.
Most of those who have been identified are alive and well.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
Unidentified women in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
Unidentified women in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified child in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified child in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
Unidentified women in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified child in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
Huntington Beach Police Dept.
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
Unidentified people in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified person in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified child in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
An unidentified woman in an image from Rodney Alcala’s photo cache.
Serial Killer’s Secret Photos
Unidentified women in an image from Rodney Alcala’s photo cache.
San Francisco Mayor London Breed conceded the mayoral race to Daniel Lurie Thursday afternoon with a social media post that congratulated her competitor.
The mayor also thanked the city and its residents for “the opportunity to serve the City that raised me” in the post on X just after 4:30 p.m. Thursday.
There had been rumblings that Breed might concede the race earlier Thursday having come in behind Lurie in the last vote count released Wednesday morning.
“Today, I called Daniel Lurie and congratulated him on his victory in this election,” the post read. “Over the coming weeks, my staff and I will work to ensure a smooth transition as he takes on the honor of serving as Mayor of San Francisco. I know we are both committed to improving this City we love.”
Breed spoke at a press conference less than an hour after the social media post to answer questions from reporters about her decision, reiterating some of what she said in her social media post.
“The city is on the rise. The office is bigger than just one person, and I called Daniel Lurie earlier today to congratulate him,” the mayor said. “And made it very clear my team and I stand ready to support him during his transition. We will always do everything we can to ensure the success of the city and that there is a smooth transition, so that the important work that has been done and needs to continue in San Francisco moves forward.”
When asked if this was the hardest speech she’d ever given, Breed quickly dismissed that idea.
“No, it’s not. There’s been other harder speeches. I mean I had to make a hard decision to close the city down during a global pandemic. I had to deal with…the racial reckoning that happened after the tragic death of George Floyd. I had to go out in the middle of the night and tell people that Mayor Ed Lee had passed away. There are numerous occasions.”
Six years ago, incumbent London Breed became the first Black woman to serve as mayor of San Francisco after the death of Mayor Ed Lee in late 2017. The then president of the San Francisco Board of Supervisors was automatically appointed as the city’s acting mayor early the morning after Lee’s death.
In June of 2018, Breed won the special election that was held to fill the office, defeating her main opponent, former state senator Mark Leno.
Breed faced a number of major challenges during her first term in office, including the COVID-19 pandemic, the city’s ongoing issues with drug abuse and homelessness, rising housing costs and a spike in retail crime that some chains cited as the reason behind closing stores in San Francisco.
While Breed has touted progress in reducing the number of homeless encampments and pushed programs to fill vacant business spaces downtown, the mayor’s struggles have led to 11 other candidates entering the race to challenge her for the job.
“Over the coming weeks, I plan to reflect on all the progress we’ve made. But today, I am proud that we have truly accomplished so much and my heart is filled with gratitude,” Breed’s message said in closing. “During my final two months as your Mayor, I will continue to lead this City as I have from Day One – as San Francisco’s biggest champion.”
Daniel Lurie has announced that he will speak to the media about the latest developments Friday morning.
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