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How Mayo Clinic became one of the world’s most famous medical centers

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More than a million people each year receive treatment at Mayo Clinic, the small southern Minnesota hospital that grew into an international destination.

Mayo’s footprint in Rochester is expanding and it has growing campuses in Florida and Arizona. Patients from nearly 130 countries visit the clinic, which is considered one of the most respected and well-known medical institutions in the world.

How did this “clinic in a cornfield” become internationally prestigious? A reader sought answers from Curious Minnesota, the Star Tribune’s reporting project fueled by reader questions.

The short answer is that Mayo attracted worldwide attention from its earliest days because of innovations that ensured patients survived surgeries. The clinic has since built a patient-focused reputation stemming largely from strong collaboration among the many specialists and other staff overseeing treatment.

Mayo has been ranked the No. 1 hospital in the world for the past five years in the global hospital rating by Newsweek and Statista. Other institutions topping the list include the Cleveland Clinic, Massachusetts General Hospital and Johns Hopkins Hospital.

The high-quality care also comes with a bigger price tag.

The average cost of health care for a patient at Mayo Clinic — $1,236 — is almost twice the Minnesota average, according to a 2022 study by Minnesota Community Measurement.

The founding of Mayo Clinic

The idea for Mayo Clinic emerged after a devastating tornado destroyed nearly a third of Rochester in 1883. Physician William Worrall Mayo and his two sons took care of injured survivors. They were joined in the relief effort by the Sisters of Saint Francis, led by Mother Alfred Moes.

After the crisis, Moes suggested her congregation join forces with the Mayo family to build a hospital together. The result was Saint Marys Hospital — the predecessor of Mayo Clinic — which opened in 1889.

The Mayo brothers, Will and Charlie, became the backbone of the clinic after graduating from medical school.

“They were in the right place at the right time,” said W. Bruce Fye, emeritus professor of medicine and history of medicine at Mayo Clinic. “And they had the right support structure with the sisters who basically gave them a hospital and staffed the hospital for them.”

It wasn’t long before the young hospital became internationally renowned for the low mortality rates of its surgeries. Surgery still had a 25% to 30% mortality rate in the late 1890s. But it was less than 2% at Saint Marys, according to an 1893 hospital report.

This was largely due to the hospital’s early adoption of aseptic techniques — a practice that prevents contamination from germs — and the nurses’ careful attention to preventing post-surgery infection. Word soon spread about the brothers’ surgical skills and the sisters’ compassionate care.

Physicians traveled from other states and countries to observe surgeries at “the Mayos’ clinic.” A Johns Hopkins surgeon, Harvey Cushing, once described the clinic as “a Mecca for medical men.” Investigative journalist Samuel Hopkins Adams wrote in 1905 that the Mayo brothers’ hospital “handles more surgical cases annually than any institutions in the United States.”

About 40% of Saint Marys patients were born outside of America in the 1890s. Men and women traveled to Rochester from ever greater distances as train tracks fanned out across the country.

In 1914, the Mayo brothers moved into a new building with more exam rooms, laboratories and surgical dressing suites. This is when the name “Mayo Clinic” was formalized, which at the time indicated that it was a place for education, according to a 2009 Mayo Clinic article.

“Many patients experienced modern medicine for the first time as diagnosticians used different technologies to examine their bodies and bodily fluids,” Fye wrote in a 2010 paper about the origins of Mayo Clinic.

Mayo Clinic received its 1 millionth patient in 1938 when Maude Neale Lumsden traveled from Salmo, British Columbia. Many prominent patients have received treatment there, including baseball great Lou Gehrig, former President George H.W. Bush and the royal family of Saudi Arabia.

A team approach

Fye said one of the Mayo brothers’ secrets of success was “there were two of them.”

While most doctors in the United States were in solo practice, the Mayo brothers could take turns. One traveled to learn new practices and attended medical meetings; the other stayed home to run the clinic.

The mutual support between the brothers and the nuns also infused a teamwork spirit into Mayo Clinic’s DNA. It represented the “first group practice” of medicine in the country, said Peter Kernahan, a medical historian at the University of Minnesota.

Nowadays, doctors and nurses at Mayo Clinic still work as a team.

Brooks Edwards, a retired cardiologist who worked at Mayo Clinic for 45 years, said he and his colleagues would meet together with individual patients each week, including people from cardiology, surgery, infectious disease, psychiatry, social work and pulmonary disease. All the providers would sit around a table to discuss the patient’s needs and how to best coordinate their care.

“The concept of a union of forces means nobody is arrogant enough to recognize that they can do it all on their own,” Edwards said. “So, we all work together.”

Doctors at Mayo Clinic constantly consult each other. Christopher Boes, a neurologist at Mayo, said he “expects to get calls every day” from different departments to consult a patient’s brain condition because he is a headache specialist.

Other top health care institutions follow a similar approach.

One of them is Cleveland Clinic, founded by George Crile, a close friend of the Mayo brothers. Fye said Cleveland Clinic was modeled after Mayo, emphasizing group practice and specializations.

Another is Johns Hopkins, where Macalester College medical anthropologist Ron Barrett once worked in the neurocritical care unit as a registered nurse. He said communications were more transparent when all health providers, patients and their family members were together when making a critical decision.

But there was room for improvement.

“There are places when I was doing my rotations at Johns Hopkins where I felt like I was stepping back into the 1950s, and other places where I was stepping into the future,” Barrett said. “The resounding message that I get about Mayo is that it does not compromise in any of its divisions with regards to making sure that the clinical care is paramount.”

Prioritizing patients

In addition to teamwork, Mayo’s other key ingredients for boosting patient care are efficiency, specialization and time.

In the early 1900s, the clinic pioneered new methods of organizing patient data when internist Henry Plummer created the “dossier” system that compiled a patient’s medical history into one folder. It was later widely implemented in other hospitals.

The dossier system has evolved at Mayo into an integrated medical record that can quickly bring patient, physician, laboratory tests, radiology reports and medical records into one room at the same time.

Mayo’s approach also relies heavily on specialists. In 1915, it partnered with the University of Minnesota to establish one of the nation’s first three-year university-based programs to train graduate physicians in specialty practice.

“Everybody at Mayo, with very few exceptions, specialized in something,” Fye said.

In the field of neurology, for example, there are 122 specialized doctors on Mayo’s Rochester campus, according to the clinic’s website directory.

Doctors have the benefit of additional patient time, as well. Among Mayo Clinic’s “Model of Care” tenets is “an unhurried examination with time to listen to the patient.”

“A lot of places have fancy imaging or technology,” Edwards said. “But they don’t have the time to sit down with the patients, explain what’s going on and hold their hand and help them through the journey.”

Mayo’s primary value in its guiding principles is “the needs of the patient come first.”

“Nowadays, every medical center has something like that,” Edwards said. “But at Mayo, it’s real.”

Grace Xue can be reached at xuegrace7@gmail.com.

If you’d like to submit a Curious Minnesota question, fill out the form below:

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Read more Curious Minnesota stories:

Why do so many Fortune 500 companies call Minnesota home?

Are Minnesota’s health care costs really the highest in the nation?

Frozen for the future: Does Minnesota have any cryonics facilities?

Minnesota was once a leader in corporate philanthropy. Is that still true?

Why was the Mall of America built in Minnesota?

Why thousands of board games are buried beneath Mankato



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Minnesota Gov. Tim Walz, on the campaign trial, gives a pep talk to the Mankato West High School Scarlets, a team he once coached.

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MANKATO – The football players in their pads jogged out to face their rivals Friday night as Gov. Tim Walz, back home briefly as he campaigns across the country as vice presidential nominee, cheered them on.

“Don’t forget to have fun, enjoy,” Walz told players on the football team at Mankato West High School, where he worked as a geography teacher and assistant football coach before launching a political career that carried him to the Democratic Party’s national ticket.

Since choosing Walz as her running mate, Democratic presidential nominee Kamala Harris has touted his background as a football coach, hunter and gun owner, as Democrats reach out to Midwestern voters and look for inroads with men.

Walz’s stop in Mankato is one of a series of media stops in the battleground states of Michigan, Wisconsin and Pennsylvania, where the governor is talking high school football and hunting.

“This is the best of America,” Walz told reporters after greeting the players of Mankato West ahead of their rivalry game with Mankato East. He said he would visit his old classroom, before heading to watch the game.

A quarter center ago, Walz was the assistant defensive football coach for the 1999 Mankato West football team that won the state championship. That year’s crosstown rivalry game was a spark for Mankato West as it headed toward its state championship, said John Considine, a Mankato West alum and right tackle on that 1999 Class 4A championship team.

“It’s good to have him back,” Considine said Friday.

Local Republicans called Walz’s appearance a stunt. “They’re getting desperate to get the word out,” said Yvonne Simon, chair of the Blue Earth County GOP, adding she’s doesn’t think the governor’s “coach” branding is catching on.



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Longtime owner of Gunflint Lodge dies at 85

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“There’s a fair amount of stuff we’ve digested over the years,” Kerfoot told the Star Tribune at the time of the sale. “It’ll take a while to pick all of it out of me.”

In recent years, he and Sue have spent summers in Minnesota and then traveled back to Missouri to be close to family for the rest of the year.

Visitors love to drop in and talk about Justine Kerfoot or Bruce Kerfoot or the years they spent working at the lodge, Fredrikson said. He’s found that Bruce’s energy seemingly matched that of his mother, who died in 2001 when she was 94.

“He was one of those people that was able to get stuff done more easily or better than other people,” Fredrikson said. “Maybe because of who he was, or maybe because the stars align for this kind of person.”

In a social media post, Kerfoot’s family said they had peace knowing he and his mother “were paddling together to their shore lunch spot.”

Mark Hennessy knew Kerfoot for 40 years, but has had a closer view for the past three years. He said without Kerfoot, the Chik-Wauk Museum and Nature Center, located near the end of the Gunflint Trail, wouldn’t exist. Whenever there was a work project, the executive director said, Kerfoot would show up.



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Motorcyclist, 17, killed in collision with SUV in Burnsville

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A teenage motorcyclist was killed in a collision with an SUV at a Burnsville intersection, officials said Friday.

The crash occurred shortly after 7:30 p.m. Thursday at Burnsville Parkway and Interstate 35W, police said.

The motorcyclist was identified by the Hennepin County Medical Examiner’s Office as Peter Vsevolod Genis, 17, of Burnsville.

An SUV driver was turning left from westbound Burnsville Parkway to northbound 35W when Genis went through a red light while heading east and struck the SUV.

The SUV driver and a woman with him, both from Burnsville, were not hurt.

The other vehicle was a Mercedes SUV. The driver was a 30-year-old male from Burnsville, with a 29-year-old female passenger from Burnsville. Neither of them was injured.



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