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Nobel Prize in medicine honors 2 Massachusetts researchers for microRNA discovery

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2 Massachusetts researchers awarded Nobel Prize in medicine


2 Massachusetts researchers awarded Nobel Prize in medicine

00:39

STOCKHOLM – Two researchers working in Massachusetts have been awarded the Nobel Prize in medicine.

MicroRNA

Americans Victor Ambros and Gary Ruvkun were honored Monday for their discovery of microRNA, a fundamental principle governing how gene activity is regulated.

The Nobel Assembly said that their discovery is “proving to be fundamentally important for how organisms develop and function.”

Announcement of the 2024 Nobel Prize - Medicine
The Secretary of the Nobel Assembly announced the winners of the 2024 Nobel Prize in Medicine, Victor Ambros and Gary Ruvkun, on October 7, 2024 in Stockholm, Sweden. 

Steffen Trumpf/picture alliance via Getty Images


Victor Ambros   

Ambrose performed the research that led to his prize at Harvard University. 

He is currently a professor of natural science at the University of Massachusetts Medical School in Worcester. Ambrose was born in Hanover, New Hampshire. He earned his PhD from the Massachusetts Institute of Technology (MIT)  in 1979.

Gary Ruvkun  

Ruvkin’s research was performed at Massachusetts General Hospital and the Harvard Medical School, where he’s a professor of genetics, said Thomas Perlmann, Secretary-General of the Nobel Committee.

Ruvkin was born in Berkeley, California. He earned his PhD from Harvard in 1982.

Nobel Prizes

Last year, the Nobel Prize in Physiology or Medicine went to Hungarian-American Katalin Karikó and American Drew Weissman for discoveries that enabled the creation of mRNA vaccines against COVID-19 that were critical in slowing the pandemic.

The prize carries a cash award of $1 million from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel.

The announcement launched this year’s Nobel prizes award season.

Nobel announcements continue with the physics prize on Tuesday, chemistry on Wednesday and literature on Thursday. The Nobel Peace Prize will be announced Friday and the Nobel Memorial Prize in Economic Sciences on Oct. 14.

The laureates are invited to receive their awards at ceremonies on Dec. 10, the anniversary of Nobel’s death.

Associated Press writers Daniel Niemann and Mike Corder contributed to this report.



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Mayor reportedly beheaded days after taking office in Mexico amid surge in cartel violence

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The mayor of a city in southern Mexico has been murdered less than a week after taking office, authorities said Sunday, the latest in a series of attacks on politicians in the violence-plagued Latin American country.

The killing of Chilpancingo mayor Alejandro Arcos “fills us with indignation,” Guerrero state governor Evelyn Salgado wrote on social media, without providing further details of the circumstances.

Local media reported that Arcos was decapitated, but there has been no official confirmation.

Reuters reported that photos circulating on WhatsApp showed a severed head on top of what appeared to be Arcos’ vehicle, but the news agency could not independently verify the photos’ authenticity.

MEXICO-CRIME-VIOLENCE
Investigators and forensic personnel work at the crime scene where remains of Chilpancingo Mayor Alejandro Arcos of the Institutional Revolutionary Party (PRI) were found in Chilpancingo, Guerrero state on October 6, 2024. 

JESUS GUERRERO/AFP via Getty Images


Arcos was elected in June representing an opposition coalition that included the Institutional Revolutionary Party (PRI), which denounced his killing as a “cowardly crime” and called for justice.

“Enough of violence and impunity! The people of Guerrero do not deserve to live in fear,” it said on X.

His murder came days after the killing of another city official, Francisco Tapia, according to PRI president Alejandro Moreno.

“They had been in office for less than a week. Young and honest officials who sought progress for their community,” Moreno said on X.

Guerrero, one of Mexico’s poorest states, has endured years of violence linked to turf wars between cartels fighting for control of drug production and trafficking.

Last year, 1,890 murders were recorded in the state, which is home to the beachside resort city of Acapulco, a former playground of the rich and famous now blighted by crime. Guerrero is among six states in Mexico that the U.S. State Department advises Americans to completely avoid, citing crime and violence.

Across Mexico, more than 450,000 people have been killed and tens of thousands have gone missing in a spiral of violence since the government deployed the army to combat drug trafficking in 2006.

Politicians, particularly at the local level, frequently fall victim to bloodshed connected to corruption and the multibillion-dollar drugs trade.

Tackling the cartel violence that makes murder and kidnapping a daily occurrence in Mexico is among the major challenges facing Claudia Sheinbaum, Mexico’s first woman president.

Sheinbaum, the former mayor of Mexico City who was sworn in on October 1, has pledged to stick to her predecessor Andres Manuel Lopez Obrador’s “hugs not bullets” strategy of using social policy to tackle crime at its roots.

She is due to unveil her security plan on Tuesday.

At least 24 politicians were murdered during a particularly violent electoral process leading up to the June election that the key ruling party figure won by a landslide, according to official figures.

In June, at least three politicians in Guerrero were killed.  Acacio Flores, who represents Malinaltepec, was killed just days after the killing of Salvador Villalba Flores, another mayor from Guerrero state elected in June 2 polls. Earlier in the month, a local councilwoman was gunned down as she was leaving her home in Guerrero.

Her murder came a few days after the mayor of a town in western Mexico and her bodyguard were killed outside of a gym, just hours after Sheinbaum won the presidency.



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Illegal crossings at U.S. southern border reach lowest point of Biden presidency

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The number of migrants crossing into the U.S. illegally at the southern border reached the lowest point of President Biden’s administration in September, three months into his crackdown on asylum claims, according to internal Department of Homeland Security statistics obtained by CBS News.

In September, U.S. Border Patrol agents recorded nearly 54,000 apprehensions of migrants who crossed into the country between legal entry points along the border with Mexico, the government figures show. It’s a smaller figure than the previous Biden-era low in July, when Border Patrol processed roughly 56,000 migrants who crossed the border without authorization. 

Border Patrol’s tally of migrant apprehensions in September is the lowest number recorded by the agency since August 2020, when the Covid-19 pandemic and the travel restrictions countries enacted in response to it led to a sharp decrease in migration to the U.S. southern border. It’s also a 78% drop from a record high in December, when illegal border crossings soared to 250,000.

U.S. immigration officials processed another 48,000 migrants in September at legal border entry points, known as ports of entry, according to the internal federal data. Most of them secured appointments to enter the U.S. via a phone app the Biden administration has transformed into the main gateway into the American asylum system.

Line chart showing the number of illegal crossings along the southern border in the past year.

September’s numbers show migration to the U.S.-Mexico border has plateaued following a precipitous drop at the start of the summer, when President Biden invoked sweeping presidential powers to disqualify most of those entering the country illegally from asylum. In July, August and September, Border Patrol agents at the southern border recorded between 54,000 and 58,000 migrant apprehensions each month. 

Designed to be temporary, Mr. Biden’s move to sharply restrict asylum is likely to remain in place indefinitely after his administration made the policy’s deactivation threshold harder to meet last week. Vice President Kamala Harris has also vowed to continue the strict measure if elected president and make it even more difficult to lift. 

The Biden administration’s support for drastic limits on asylum reflect a broader rightward shift on border policy by Democrats that would have been unthinkable in 2020, when the party faced pressure to reverse the Trump administration’s hardline immigration rules. It’s a shift that has occurred amid a marked increase in support for tough immigration measures among the American public.

The dramatic reduction in illegal border crossings this year, however, has given Democrats a much-needed political win on immigration ahead of the presidential election next month. Former President Donald Trump, who is pledging to carry out mass deportations if voters return him to the White House, has sought to make immigration a defining issue of the 2024 race for the president.

With September’s tally, fiscal year 2024 saw the lowest level in unlawful border crossings under the Biden administration. Border Patrol recorded over 1.5 million migrant apprehensions in fiscal year 2024, compared to a record high of 2.2 million in fiscal year 2022.

While the Mexican government’s efforts have also played a major role in the lower number of migrant arrivals along the U.S. border this year, American officials have credited Mr. Biden’s stringent asylum rules in June for the current four-year low in illegal immigration levels.

During its first three years in office, the Biden administration struggled to respond to an unprecedented migrant influx that was, in great part, fueled by arrivals from far-flung countries, including nations like Venezuela where the U.S. cannot deport migrants on a regular basis due to frosty diplomatic relations. In many cases, migrants were released into the U.S. with notices to appear in immigration court simply because the government did not have the resources and personnel to vet their asylum claims at the border.  

But since Mr. Biden’s partial ban on asylum claims took effect, there has been an 80% drop in migrant releases, a senior Customs and Border Protection official told CBS News, requesting anonymity to speak candidly about migration trends. The U.S. government has long viewed migrant releases as a “pull” factor that fuels migration to the southern border, alongside economic conditions and other “push” factors in migrants’ home countries.

More than 70% of migrant adults and families apprehended by Border Patrol have been deported from the U.S. since Mr. Biden’s asylum crackdown began, up from 25% in May, according to DHS data. Since the policy took effect, the U.S. has carried out over 121,000 returns and deportations of migrants.

The asylum restrictions do not apply to unaccompanied children or those with acute medical conditions. It also exempts more than 1,000 migrants who enter the U.S. at legal border entry points each day under the phone app-power appointment system. The Biden administration has paired that process and other legal migration channels, including a program that allows migrants from four countries to fly to the U.S. if they have American sponsors, with the asylum restrictions to deter unlawful crossings through a carrots-and-sticks strategy. 

While it has arguably been responsible for ending, at least temporarily, large-scale illegal crossings and chaotic images at the U.S.-Mexico border, the Biden administration’s asylum crackdown has been derided as an election gimmick by Republican lawmakers and a draconian policy by migrant advocates, who are challenging the policy in court. 

In a conference hosted by the Migration Policy Institute last week, Homeland Security Secretary Alejandro Mayorkas challenged those critical of the asylum restrictions to find an “alternative proposal,” calling the situation at the border before the policy change “unworkable.”

“We have to understand the fact that the American public does want, does expect and does demand the delivery of order,” Mayorkas said, adding later, “And I would respectfully submit that, at least in particular times over the past three years, we haven’t had order.”



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