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Grandmother who received first-ever combined heart pump and pig kidney transplant dies at 54

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A grandmother died on Sunday, months after she received a combined mechanical heart pump and gene-edited pig kidney transplant, according to the hospital that performed the surgeries. 

Lisa Pisano, 54, was suffering from heart and kidney failure before the surgeries and was ineligible for a human transplant. She received the heart pump, called an LVAD, on April 4 and the pig kidney transplant on April 12. In May, 47 days after the transplant, doctors removed the genetically engineered organ because it was interfering with her blood flow. 

“Lisa’s contributions to medicine, surgery, and xenotransplantation cannot be overstated,” Dr. Robert Montgomery, director of the NYU Langone Transplant Institute, said in a statement Tuesday. “Her legacy as a pioneer will live on and she will forever be remembered for her courage and good nature.”

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Dr. Robert Montgomery and his team prepare the surgical site for xenotransplantation surgery for Lisa Pisano on April 12, 2024, at NYU Langone Health.

Joe Carrotta for NYU Langone Health


Before the two procedures, Pisano faced heart failure and end-stage kidney disease that required routine dialysis. 

“I was pretty much done,” Pisano told CBS News chief medical correspondent Dr. Jon LaPook, who is also a professor at NYU Langone, in an April interview. “I couldn’t go up the stairs. I couldn’t drive. I couldn’t play with my grandkids. So when this opportunity came to me I was taking it.” 

After the procedures, she told LaPook she felt “great today compared to other days.”

Around 104,000 people in the U.S. are on the waiting list for a transplant, with more than 80% of those patients waiting for a kidney, NYU Langone said. Across the U.S., nearly 808,000 people are suffering from end-stage kidney disease, but only about 27,000 received transplants last year.

Pisano’s implant was only the second transplant of a gene-edited pig kidney into a living person, the hospital said. Surgeons had previously tested a pig kidney transplant on brain-dead patients.

In March, surgeons at Massachusetts General Hospital in Boston transplanted a pig kidney into 62-year-old Rick Slayman. He died in May. The hospital said there was no indication his death was a result of the transplant.

Montgomery said Pisano’s bravery in trying a genetically modified pig kidney gave hope to people awaiting transplants about the possibility of an alternative supply of organs. 

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The gene-edited pig kidney with thymus is removed from its transport container to be prepared for transplantation on April 12, 2024, at NYU Langone Health.

Joe Carrotta for NYU Langone Health


“Lisa helped bring us closer to realizing a future where someone does not have to die for another person to live,” the doctor said.

Historically, animal-to-human transplants have not been compatible, Montgomery told LaPook in 2021 after a transplant. 

“When you cross species with a transplant and it happens immediately, humans have preformed antibodies circulating in their blood,” he said. “And so when you put an organ from a pig into a human, it’s immediately rejected.”

The pig kidney Pisano received was genetically engineered to “knock out” the gene responsible for the production of a sugar known as alpha-gal, NYU Langone said in April. Studies have shown that removing the alpha-gal can prevent the reaction that causes an immediate rejection of the transplanted organ. 

“By using pigs with a single genetic modification, we can better understand the role one key stable change in the genome can have in making xenotransplantation a viable alternative,” Montgomery said in a statement earlier this year. “Since these pigs can be bred and do not require cloning like more-complex gene edits, this is a sustainable, scalable solution to the organ shortage. If we want to start saving more lives quickly, using fewer modifications and medications will be the answer.”



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Gazan chefs cook up hope and humanity for online audience

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Renad Atallah is an unlikely internet sensation: a 10-year-old chef, with a repertoire of simple recipes, cooking in war-torn Gaza. She has nearly a million followers on Instagram, who’ve witnessed her delight as she unpacks parcels of food aid.

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Ten-year-old Renad Atallah posts videos of herself cooking in war-torn Gaza.

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We interviewed Renad via satellite, though we were just 50 miles away, in Tel Aviv. [Israel doesn’t allow outside journalists into Gaza, except on brief trips with the country’s military.]

“There are a lot of dishes I’d like to cook, but the ingredients aren’t available in the market,” Renad told us. “Milk used to be easy to buy, but now it’s become very expensive.”

I asked, “How does it feel when so many people like your internet videos?”

“All the comments were positive,” she said. “When I’m feeling tired or sad and I want something to cheer me up, I read the comments.”

We sent a local camera crew to Renad’s home as she made Ful, a traditional Middle Eastern bean stew. Her older sister Noorhan says they never expected the videos to go viral. “Amazing food,” Noorhan said, who added that her sibling made her “very surprised!”

After more than a year of war, the Gaza Strip lies in ruins. Nearly everyone has been displaced from their homes. The United Nations says close to two million people are experiencing critical levels of hunger.

Hamada Shaqoura is another chef showing the outside world how Gazans are getting by, relying on food from aid packages, and cooking with a single gas burner in a tent.

Shaqoura also volunteers with the charity Watermelon Relief, which makes sweet treats for Gaza’s children.

In his videos online, Shaqoura always appears very serious. Asked why, he replied, “The situation does not call for smiling. What you see on screen will never show you how hard life is here.”

Before dawn one recent morning in Israel, we watched the UN’s World Food Program load nearly two dozen trucks with flour, headed across the border. The problem is not a lack of food; the problem is getting the food into the Gaza Strip, and into the hands of those who desperately need it.

The UN has repeatedly accused Israel of obstructing aid deliveries to Gaza. Israel’s government denies that, and claims that Hamas is hijacking aid.

“For all the actors that are on the ground, let the humanitarians do their work,” said Antoine Renard, the World Food Program’s director in the Palestinian territories.

I asked, “Some people might see these two chefs and think, well, they’re cooking, they have food.”  

“They have food, but they don’t have the right food; they’re trying to accommodate with anything that they can find,” Renard said.

Even in our darkest hour, food can bring comfort. But for many in Gaza, there’s only the anxiety of not knowing where they’ll find their next meal.

      
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Story produced by Mikaela Bufano. Editor: Carol Ross. 

      
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“Sunday Morning” 2024 “Food Issue” recipe index
Delicious menu suggestions from top chefs, cookbook authors, food writers, restaurateurs, and the editors of Food & Wine magazine.  



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A study to devise nutritional guidance just for you

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It’s been said the best meals come from the heart, not from a recipe book. But at this USDA kitchen, there’s no pinch of this, dash of that, no dollops or smidgens of anything. Here, nutritionists in white coats painstakingly measure every single ingredient, down to the tenth of a gram.

Sheryn Stover is expected to eat every crumb of her pizza; any tiny morsels she does miss go back to the kitchen, where they’re scrutinized like evidence of some dietary crime.

Stover (or participant #8180, as she’s known) is one of some 10,000 volunteers enrolled in a $170 million nutrition study run by the National Institutes of Health. “At 78, not many people get to do studies that are going to affect a great amount of people, and I thought this was a great opportunity to do that,” she said.

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Sheryn Stover participates in the Nutrition for Precision Health Study, to help tailor dietary recommendations according to an individual’s genes, culture and environment.

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It’s called the Nutrition for Precision Health Study. “When I tell people about the study, the reaction usually is, ‘Oh, that’s so cool, can I do it?'” said coordinator Holly Nicastro.

She explained just what “precise” precisely means: “Precision nutrition means tailoring nutrition or dietary guidance to the individual.”

The government has long offered guidelines to help us eat better. In the 1940s we had the “Basic 7.” In the ’50s, the “Basic 4.” We’ve had the “Food Wheel,” the “Food Pyramid,” and currently, “My Plate.”

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They’re all well-intentioned, except they’re all based on averages – what works best for most people, most of the time. But according to Nicastro, there is no one best way to eat. “We know from virtually every nutrition study ever conducted, we have inner individual variability,” she said. “That means we have some people that are going to respond, and some people that aren’t. There’s no one-size-fits-all.”

The study’s participants, like Stover, are all being drawn from another NIH study program called All Of Us, a massive undertaking to create a database of at least a million people who are volunteering everything from their electronic health records to their DNA.  It was from that All of Us research that Stover discovered she has the gene that makes some foods taste bitter, which could explain why she ate more of one kind of food than another.

Professor Sai Das, who oversees the study at Tufts University, says the goal of precision nutrition is to drill down even deeper into those individual differences. “We’re moving away from just saying everybody go do this, to being able to say, ‘Okay, if you have X, Y and Z characteristics, then you’re more likely to respond to a diet, and somebody else that has A, B and C characteristics will be responding to the diet differently,'” Das said.

It’s a big commitment for Stover, who is one of 150 people being paid to live at a handful of test sites around the country for six weeks – two weeks at a time. It’s so precise she can’t even go for a walk without a dietary chaperone. “Well, you could stop and buy candy … God forbid, you can’t do that!” she laughed.

While she’s here, everything from her resting metabolic rate, her body fat percentage, her bone mineral content, even the microbes in her gut (digested by a machine that essentially is a smart toilet paper reading device) are being analyzed for how hers may differ from someone else’s. 

Nicastro said, “We really think that what’s going on in your poop is going to tell us a lot of information about your health and how you respond to food.”  

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Microbiome analysis – studying microbes and genetic material found in the stool samples of program participants – is one of the components of the Nutrition for Precision Health Study. 

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Stover says she doesn’t mind, except for the odd sounds the machine makes. While she is a live-in participant, thousands of others are participating from their homes, where electronic wearables track all kinds of health data, including special glasses that record everything they eat, activated when someone starts chewing. Artificial intelligence can then be used to determine not only which foods the person is eating, but how many calories are consumed.

This study is expected to be wrapped up by 2027, and because of it, we may indeed know not only to eat more fruits and vegetables, but what combination of foods is really best for us.  The question that even Holly Nicastro can’t answer is, will we listen? “You can lead a horse to water; you can’t make them drink,” she said. “We can tailor the interventions all day. But one hypothesis I have is that if the guidance is tailored to the individual, it’s going to make that individual more likely to follow it, because this is for me, this was designed for me.”

      
For more info:

     
Story produced by Mark Hudspeth. Editor: Ed Givnish. 


“Sunday Morning” 2024 “Food Issue” recipe index
Delicious menu suggestions from top chefs, cookbook authors, food writers, restaurateurs, and the editors of Food & Wine magazine.



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A new generation of shopping cart, with GPS and AI

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A new generation of shopping cart, with GPS and AI – CBS News


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At a Price Chopper outside Kansas City, shoppers are test driving the new Caper Cart, featuring digital screens, GPS, cameras equipped with artificial intelligence, and packaging scanners that spit out coupons. Correspondent Jonathan Vigliotti looks at the technology used to “reinvent the wheel” of the shopping cart.

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